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L-Citrulline

Also known as Citrulline, Citrulline malate

What it is: Amino acid involved in the urea cycle
What it does: Increases plasma arginine and nitric oxide production, supporting blood flow and ammonia clearance
Status: Widely used supplement
Evidence: Moderate. Moderate human data.
Uses: Exercise performance; blood flow; cardiovascular support

Caution. Generally well tolerated; may lower blood pressure slightly.

Summary

L-citrulline is a non-essential amino acid that raises plasma arginine and nitric oxide more effectively than arginine itself in many contexts. It is used to support exercise performance, blood flow, and cardiovascular function, and is often preferred over straight arginine due to better absorption and tolerability. It can be taken as plain citrulline or as citrulline malate in pre-workout formulas.

Checked Jul 19, 2026.

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This entry summarises published information in plain language. It is not medical advice, a dosing recommendation or a substitute for a qualified healthcare professional. Many peptides are not approved for human use, and legal status varies by country. Check anything you rely on against primary sources.