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HMB

Also known as Beta-hydroxy beta-methylbutyrate

What it is: Leucine metabolite
What it does: Supports muscle protein turnover and may reduce exercise-induced muscle breakdown
Status: Widely used supplement
Evidence: Moderate. Moderate human data.
Uses: Muscle preservation in older adults; recovery; lean mass support

Caution. Generally well tolerated; effects may be more pronounced in untrained or older individuals.

Summary

HMB is a metabolite of the amino acid leucine that influences muscle protein turnover and may reduce exercise-induced muscle breakdown. It is often used by older adults or during periods of immobilization or calorie restriction to help preserve lean mass. Benefits appear largest in untrained or catabolic states, with more modest effects in well-trained individuals.

Checked Jul 19, 2026.

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This entry summarises published information in plain language. It is not medical advice, a dosing recommendation or a substitute for a qualified healthcare professional. Many peptides are not approved for human use, and legal status varies by country. Check anything you rely on against primary sources.