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MOTS-C

Also known as MOTS-c

What it is: Mitochondrial-derived peptide
What it does: Studied for metabolic and exercise-related signaling
Status: Experimental
Evidence: Low. Mostly preclinical and early translational research.
Uses: Metabolic health; endurance; aging research

Caution. Still early-stage with limited human evidence.

Summary

MOTS-c is a small peptide encoded in mitochondrial DNA that acts as a retrograde signal to the nucleus, influencing metabolism and stress responses. Animal and early human work links it to improved insulin sensitivity and exercise adaptation. Clinical evidence is still nascent, with no established therapeutic indications.

Checked Jul 15, 2026.

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This entry summarises published information in plain language. It is not medical advice, a dosing recommendation or a substitute for a qualified healthcare professional. Many peptides are not approved for human use, and legal status varies by country. Check anything you rely on against primary sources.