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Glycine

Supplement reference entry

What it is: Simplest amino acid and neurotransmitter
What it does: Supports collagen synthesis, glutathione production, and inhibitory neurotransmission
Status: Widely used supplement
Evidence: Low to Moderate. Emerging human data.
Uses: Sleep quality; joint and skin support; metabolic protocols

Caution. Generally well tolerated; high doses may cause mild GI upset.

Summary

Glycine is the simplest amino acid and serves as a building block for collagen, a component of glutathione, and an inhibitory neurotransmitter in the CNS. It is used to support sleep quality, skin and joint health, and as part of methylation and detoxification protocols. Human data are promising but still developing compared to more established supplements.

Checked Jul 19, 2026.

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This entry summarises published information in plain language. It is not medical advice, a dosing recommendation or a substitute for a qualified healthcare professional. Many peptides are not approved for human use, and legal status varies by country. Check anything you rely on against primary sources.