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Caffeine

Also known as Caffeine anhydrous, Coffee extract

What it is: Central nervous system stimulant
What it does: Blocks adenosine receptors and increases catecholamine signaling
Status: Widely used supplement
Evidence: High. Extensive human data.
Uses: Alertness; exercise performance; cognitive support

Caution. Can cause insomnia, anxiety, or palpitations at high doses; tolerance develops.

Summary

Caffeine is a widely consumed CNS stimulant that blocks adenosine receptors and increases catecholamine signaling, leading to greater alertness and reduced perceived effort. It is one of the most proven ergogenic aids for endurance and strength performance and is also used for cognitive support. Sensitivity varies widely, and high or late doses can impair sleep and increase anxiety.

Checked Jul 19, 2026.

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This entry summarises published information in plain language. It is not medical advice, a dosing recommendation or a substitute for a qualified healthcare professional. Many peptides are not approved for human use, and legal status varies by country. Check anything you rely on against primary sources.